2004/9-2008/6， 湖南師范大學(xué)，生物基地，學(xué)士

2008/9-2011/6， 華南理工大學(xué)，發(fā)酵工程，碩士

2011/8-2012/8，中國科學(xué)院廣州生物醫藥與健康研究院，研究實(shí)習員

2012/9-2015/6， 中國科學(xué)院大學(xué)，生物化學(xué)與分子生物學(xué)，博士

2015/7-至今，中國科學(xué)院廣州生物醫藥與健康研究院，助理研究員，副研究員

1. 線(xiàn)粒體DNA在發(fā)育、衰老和疾病中的作用機制；

2. 線(xiàn)粒體生物學(xué)。

1. 國家重點(diǎn)研發(fā)計劃“干細胞及轉化研究”重點(diǎn)專(zhuān)項（2017，學(xué)術(shù)骨干）?

2. 廣東省自然科學(xué)基金面上項目（2021，項目負責人）

3. 廣東省自然科學(xué)基金自由申請（2018，項目負責人）

4. 廣東省省級科技計劃項目（2017，項目負責人）

5. 廣州市科技計劃項目基礎研究計劃（2021，項目負責人）

6. 廣州市科技計劃項目一般項目（2017，項目負責人）

7. 基因功能與調控教育部重點(diǎn)實(shí)驗室開(kāi)放研究基金課題（2018，項目負責人）

1. 第一屆全國博士后創(chuàng )新創(chuàng )業(yè)大賽銀獎（2021，項目負責人）

2. 廣東省科學(xué)技術(shù)獎自然科學(xué)一等獎（2020，6/15）

3. 冷泉港亞洲線(xiàn)粒體會(huì )議并列第一名（共二人，2015）。

4. 第12屆亞洲線(xiàn)粒體生物醫學(xué)及研究學(xué)會(huì )國際會(huì )議暨第六屆中國線(xiàn)粒體學(xué)會(huì )學(xué)術(shù)會(huì )議海報獎（2015）

1. Hu?Z#, Yang?L#, Zhang?M#, Tang?H, Huang?Y, Su?Y, Ding?Y, Li?C, Wang?M, Zhou?Y, Zhang?Q, Guo?L, Wu?Y, Wang?Q, Liu?N, Kang?H, Wu?Y, Yao?D, Li?Y, Ruan?Z,?Wang?H, Bao?F, Liu?G, Wang?J, Wang?Y, Wang?W, Lu?G, Qin?D, Pei?D, Chan?W, Liu X*. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development.?[J] Cell Metabolism, 2024, 36:1-36 (#，共同第一作者)
2. Yang L#, Ruan Z#, Lin X #, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, Qin D, Lu G, Loomes K, Chan W, Liu X*.?NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. [J]Nature Communications, 2024, 15(1):546?
3. Yang L#, Lin X #, Tang H, Fan Y, Zeng S, Jia L, Li Y, Shi Y, He S, Wang H, Hu Z, Gong X, Liang X, Yang Y, Liu X*. Mitochondrial DNA mutation exacerbates female reproductive ageing via impairment of the NADH/NAD+ redox. [J] Aging cell. 2020, 19(9):e13206
4. Yang L#, Long Q, Liu J, Tang H, Li Y, Bao F, Qin D, Pei D, Liu X*.?Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA.?[J]?Cell Mol Life Sci. 2015,?72(13):2585-98
5. Yang L#, Tang H#, Lin X, Wu Y, Zeng S, Pan Y, Li Y, Xiang G, Lin Y, Zhuang S, Song Z, Jiang Y, Liu X*. OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. [J] Front Cell Dev Biol, 2020，8:180
6. Yang L#, Mei T, Lin X, Tang?H, Wu Y, Wang R, Liu J, Shah Z, Liu X*. (2016). Current approaches to reduce or eliminate mitochondrial?DNA mutations.[J]?Sci China Life Sci.?2016, 59(5):532-5
7. ……Yang L#…… ?……Liu X*……. Biomarkers of Aging. Sci China Life Sci.?2023.?66(5):893-1066. ?(共一，按姓氏排名)
8. Hong WX#, Yang L#, Chen M#, Yang X, Ren X, Fang S, Ye J, Huang H, Peng C, Zhou L, Huang X, Yang F, Wu D, Zhuang Z, Liu J*. Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells.?[J]?Toxicol Appl Pharmacol. 2012, 263(2):259-72?
9. Tang H#, Hu Z#, Yang L#, Ruan Z, Wang H, Zhou Y, Bao F, Liu X*. OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation. Mitochondrial Communications. 2023.1:16-22.
10. Xiang?G, Yang?L, Long?Q, Chen?K, Tang?H, Wu?Y, Liu?Z, Zhou?Y, Qi?J, Zheng?L, Liu W, Ying?Z, Fan?W, Shi?H, Li?H, Lin?X, Gao?M, Liu?J, Bao?F, Li?L, Duan?L, Li?M, Liu X*. BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming. Autophagy.?2017, 13(9):1543-1555.?
11. Liu X*, Yang L, Long Q, Weaver?D, Hajnoczky?G*.Choosing proper fluorescent dyes, imaging techniques to study mitochondrial dynamics in mammalian cells. Biophys Rep. 2017, 3 (4-6): 64-72.??
12. Ying Z，Chen K，Zheng L，Wu Y，Li L，Wang R，Long Q，Yang L，Guo J，Yao D，Li Y，Bao F，Xiang G，Liu J，Huang Q，Wu Z，Hutchins AP，Pei D，Liu X*. Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming. [J] Cell Metabolism. 2016, 23(1):220-226.
13. Ying Z, Xiang G, Zheng L, Tang H, Duan L, Lin X, Zhao Q, Chen K, Wu Y, Xing G, Lv Y, Li L, Yang L, Bao F, Long Q, Zhou Y, He X, Wang Y, Gao M, Pei D, Chan WY, Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 2018, 28(6):935-945.?
14. Li S, Guo J, Ying Z, Chen S, Yang L, Chen K, Long Q, Qin D, Pei D, Liu X*.Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mPTP opening dependent apoptotic sensitivity in an iPSC model.?[J]?Hepatology. 2015, 61(5):1730-9.?
15. Zhou Y, Long Q, Wu H, Li W, Qi J, Wu Y, Xiang G, Tang H,?Yang L, Chen K, Li L, Bao F, Li H, Wang Y, Li M, Liu X*, Topology-dependent, bifurcated mitochondrial quality control under starvation.?[J]?Autophagy. 2019, 4:1-13.?
16. Guo?J, Duan?L, He?X, Li?S, Wu?Y,??Xiang?G, Bao?F,?Yang?L, Shi?H, Gao?M, Zheng?L, Hu?H, ?Liu?X*.A Combined Model of Human iPSC-Derived Liver?Organoids and Hepatocytes Reveals Ferroptosis in DGUOK?Mutant mtDNA Depletion Syndrome. [J]?Advanced Science. 2021, 2004680
17. Long Q, Zhou?Y, Wu?H, Du?S, Hu?M, Qi J, Li?W, Guo?J, Wu Y, Yang?L, Xiang?G, Wang?L, Ye?S, Wen?J,?Mao?H, Wang?J, Zhao?H, Chan W, Liu J, Chen Y, Li P, Liu?X*. Phase separation drives the self-assembly of?mitochondrial nucleoids for transcriptional?modulation. Nature Struc & Mol Biology. 2021. 28(11):900-908.
18. Bao F, Zhou?L, Zhou?R, Huang?Q, Chen?J, Zeng?S, Wu?Y, Yang?L, Qian?S, Wang?M, He?X, Liang?S, Qi?J, Xiang?G, Long?Q, Guo?J, Ying?Z, Zhou?Y, Zhao?Q, Zhang?J, Zhang?D,?Sun?W, Gao?M, Wu?H, Zhao?Y, Nie?J, Li?M, Chen?Q, Chen?J, Zhang?X, Pan?G, Zhang?H, Li?M, Tian?M,*, Liu?X*?Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms.?Science Advances.2022, 8:eabk2376.
19. Yao?D, Li Y, Zeng S, Li Z, Shah Z, Song Z, Liu J, Wu?Y, Yang?L, Long Q, Wang W, Hu Z, Tang?H, Liu X*. ?Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.?Sci China Life Sci. 2022,?65(2):227-235
20. Lin YF, Xiao MH, Chen HX, Meng Y, Zhao N,?Yang L, Tang H, Wang JL, Liu X*, Zhu Y*, Zhuang SM*.?A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. [J]. Cell Death Dis.?2019, 10(7):528.?
21. Bao F, Shi H, Gao M, Yang L, Zhou L, Zhao Q, Wu Y, Chen K, Xiang G, Long Q Guo J, Zhang J,?Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death Dis, 2018, 9(10):966.?
22. Bao F, Shi H, Long Q, Yang L, Wu Y, Ying Z, Qin D, Zhang J, Guo Y, Li H, Liu X*. Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration.?[J] CNS Neurosci Ther.?2016, 22(8):648-60.
23. Long Q, Zhao D, Fan W, Yang L, Zhou Y, Qi J, Wang X*, Liu X*. Modeling of Mitochondrial Donut Formation. [J] Biophysical Journal. 2015, 109(5): 892-899.

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授權專(zhuān)利

1. 劉興國，楊亮，林曉冰，唐海特，檢測mtDNA突變的方法和系統，2022-05-06，中國，CN111621552B，201910509687.4
2. 劉興國，楊亮，唐海特，Opa1 異形體蛋白在調控肝癌細胞增殖能力中的用途，2022-06-06，中國，CN111518898A，201910105768.8