RNA與RNA結合蛋白的相互作用在基因表達調控中的機理研究，非編碼RNA以及RNA結合蛋白在腫瘤中的功能以及作用機制研究。

招生方向：

生物化學(xué)與分子生物學(xué)
細胞生物學(xué)
化學(xué)生物學(xué)

1. Menghui Yin?(尹夢(mèng)回）#*,?Meidie Cheng#,?Chengli Liu#,?Keli Wu,?Wei Xiong,?Ji Fang,?Yinxiong Li,?Biliang Zhang*.?HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6.?iScience.?2021,?24(11), 103345,DOI:10.1016/j.isci.2021.103345.
2. Tingting Xu#*, Qingqing Gan, Bin Wu,?Menghui Yin(尹夢(mèng)回）, Jinxin Xu,?Xiaodong Shu?and Jinsong Liu*.?Molecular Basis for PI(3,5)P2?Recognition by SNX11, a Protein?Involved in Lysosomal?Degradation and Endosome?Homeostasis Regulation.?Journal of Molecular Biology. 2020 Jul 24;432(16):4750-4761. ?
3. Linlin Hou*, Yuanjie Wei, Yingying Lin, Xiwei Wang,?Yiwei Lai,?Menghui Yin?(尹夢(mèng)回）,Yanpu Chen, Xiangpeng Guo,?Senbin Wu,?Yindi Zhu,?Jie Yuan,?Muqddas Tariq,?Na Li, Hao Sun, Huating Wang,?Xiaofei Zhang,?Jiekai Chen,?Xichen Bao*,?Ralf Jauch*.?Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2.?Nucleic Acids Research.?2020, 2(3).
4. Xichen Bao#*, Xiangpeng Guo#?,?Menghui Yin#?(尹夢(mèng)回）, Muqddas Tariq, Yiwei Lai, Shahzina Kanwal, Jiajian Zhou, Na Li, Yuan Lv, Carlos Pulido-Quetglas, Xiwei Wang, Lu Ji, Muhammad J Khan, Xihua Zhu, Zhiwei Luo, Changwei Shao, Do-Hwan Lim , Xiao Liu, Nan Li, Wei Wang, Minghui He, Yulin Liu, Carl Ward, Tong Wang, Gong Zhang, Dongye Wang, Jianhua Yang, Yiwen Chen, Chaolin Zhang, Ralf Jauch, Yungui Yang, Yangming Wang, Baoming Qin, Minna-Liisa Anko, Andrew P Hutchins,?Hao Sun, Huating Wang, Xiang-Dong Fu, Biliang Zhang*, Miguel A Esteban*. " Capturing the interactome of newly transcribed RNA. Nature Methods. 2018 Mar;15(3):213-220.
5. Menghui Yin?(尹夢(mèng)回）#^?, Xiaoshuai?Ren?#^?, Zhang Xin, Luo Yingjun, Wang Guoxin, Huang Kaili, Feng Shipeng, Bao Xicheng, Huang Ke, He Xiaoping, Liang Peizhou, Wang Zhe, Tang Hailing, He Jianxing*, Zhang Biliang*. Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation. Oncogene.?2015, 34(6):691 ?
6. Xiaoshuai Ren, Menghui Yin?(尹夢(mèng)回）, Xin Zhang, Zhe Wang, Shipeng Feng, Guoxin Wang, ??Yingjun Luo, Peizhou Liang, Xiuqun Yang, Jianxing He*?and Biliang Zhang*, Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells. Cancer Letters.?2014,344(2),195-203,
7. Xichen Bao*, Haitao Wu, Xihua Zhu, Xiangpeng Guo, Andrew P Hutchins, Zhiwei Luo, Hong Song ?, Yongqiang Chen, Keyu Lai, Menghui Yin?(尹夢(mèng)回）, Lingxiao Xu, Liang Zhou, Jiekai Chen, Dongye Wang , Baoming Qin, Jon Frampton, Hung-Fat Tse, Duanqing Pei, Huating Wang, Biliang Zhang, Miguel A Esteban*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Research. 2015. 25. 80-92.
8. Shipeng Feng, Shujie Cong, Xin Zhang, Xichen Bao, Wei Wang, Huiping Li, Zhe Wang, Guoxin Wang, Jianzhen Xu, Bowen Du, Dezhong Qu, Wei Xiong, Menghui Yin?(尹夢(mèng)回）, Xiaoshuai Ren, Feifei Wang, Jianxing He and Biliang Zhang. MicroRNA-192 targeting retinoblastoma 1 (RB1) inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Research. 2011(39): Issue 15 Pp. 6669-6678.
9. Yuehua?Xiao, Menghui?Yin(尹夢(mèng)回）, Lei?Hou, Yan?Pei*. Direct amplification of intron-containing hairpin RNA construct from genomic DNA. Biotechniques.?2006 Nov;41(5):548, 550, 552.
10. Yuehua?Xiao, Menghui?Yin(尹夢(mèng)回）, Lei?Hou, Ming?Luo, Yan?Pei*. Asymmetric overlap extension PCR method bypassing intermediate purification and the amplification of wild-type template in site-directed mutagenesis.Biotechnology Letters.?Volume 29, Number 6: 925-930,2007?

專(zhuān)利申請：

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1. 一種捕獲核酸結合蛋白的方法和試劑盒。申請號：201710080808.9。公開(kāi)號：CN108427000A。公開(kāi)日：2021.06.08。發(fā)明人：張必良，米格爾·埃斯特班，鮑習琛，郭亨彭，尹夢(mèng)回，王瑋，克雷格·梅洛。

2. ?一種核酸分子及其應用。申請號：CN201210071712.3。公開(kāi)號：CN102533770A。公開(kāi)日：2012.07.04。發(fā)明人：張必良?，尹夢(mèng)回，馮世鵬，王瑋，克雷格·梅洛。??