教育經(jīng)歷
2022.07-2024.06,中國科學(xué)院廣州生物醫藥與健康研究院,博士后
2017.09-2022.06,中國科學(xué)院廣州生物醫藥與健康研究院,藥物化學(xué),博士
2013.09-2017.06,華南農業(yè)大學(xué),制藥工程,學(xué)士
工作經(jīng)歷
2025.01-至今,中國科學(xué)院廣州生物醫藥與健康研究院,副研究員
2024.07-2024.12,中國科學(xué)院廣州生物醫藥與健康研究院,助理研究員
表觀(guān)遺傳調控靶標抗腫瘤靶向藥物研究。
1.?國家自然科學(xué)基金青年項目,22307116,2024.01-2026.12,主持;
2、中國博士后科學(xué)基金面上項目,2023M733518,2023.03-2024.07,主持;
3、廣州市基礎研究計劃基礎與應用基礎研究-青年博士“啟航”項目,2025A04J4520,2025.01-2026.12,主持;
4、國家自然科學(xué)基金面上項目,82173745,2022.01-2025.12,參與;
5、呼吸疾病全國重點(diǎn)實(shí)驗室自主項目,SKLRD-Z-202217,2022.01-2024.12,參與;
6、國家重點(diǎn)研發(fā)計劃項目,2019YFE0123700,2020.12-2023.11,參與;
7、廣州市基礎研究計劃基礎與應用基礎研究項目,202102080215,2021.04-2023.03,參與。
1、Junhua Li1, QingQing Hu1, Run Zhu1, Ruibo Dong, Hui Shen, Jiankang Hu, Cheng Zhang, Xiaohan Zhang, Tingting Xu, Qiuping Xiang, Yan Zhang, Bin Lin, Linxiang Zhao,* Xishan Wu,* Yong Xu*. Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors. Journal of Medicinal Chemistry 2024, 67, 21577-21616.
2、Junhua Li1, Cheng Zhang1, Hongrui Xu, Chao Wang, Ruibo Dong, Hui Shen, Xiaoxi Zhuang, Xiaoshan Chen, Qiu Li, Jibu Lu, Maofeng Zhang, Xishan Wu, Kerry M. Loomes, Yulai Zhou, Yan Zhang, Jinsong Liu, Yong Xu*. Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. Journal of Medicinal Chemistry 2022, 65, 5760-5799.
3、Junhua Li, Run Zhu, Xiaoxi Zhuang, Cheng Zhang, Hui Shen, Xishan Wu, Maofeng Zhang, Cen Huang, Qiuping Xiang, Linxiang Zhao, Yong Xu*, Yan Zhang*. Rational Design, Synthesis and Biological Evaluation of Benzo[d]isoxazole Derivatives as Potent BET Bivalent Inhibitors for Potential Treatment of Prostate Cancer. Bioorganic Chemistry 2023, 135, 106495.
4、Run Zhu1, Junhua Li1*, Ruibo Dong, Qingqing Hu, Zhiming Chen, Xiaoshan Chen, Zhixin Zhong, Qiuping Xiang, Cen Huang, Bin Lin, Xishan Wu, Yan Zhang, Linxiang Zhao*, Yong Xu*. Optimization of the Synthesis of BET BD2 Selective Inhibitor XY153. Chemistry & Biodiversity 2024, e202301584.
5、Qiu Li1, Benqiang Yao1, Shiting Zhao, Zhou Lu, Yan Zhang, Qiuping Xiang, Xishan Wu, Haonan Yu, Cheng Zhang, Junhua Li, Xiaoxi Zhuang, Donghai Wu, Yong Li*, and Yong Xu*. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. Journal of Medicinal Chemistry 2022,65,7193-7211.
6、Hui Shen,Hongrui Xu,Weiqin Jin,Tianbang Wu,Jiankang Hu,Cheng Zhang,Zhixin Zhong,Junhua Li,Rui Mao,Sheng Zhang,Xiao Zhang,Xishan Wu,Jeff Smaill,Jinxin Xu,Yan Zhang*;Xu,Yong*. Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-resistant Prostate Cancer. Journal of Medicinal Chemistry 2024,68,1553-1571.